General Information
SPKB ID SPKB06255
Signal sequence MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKA
Length 54
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..54
Activity Information
Pathway SRP-dependent
Natural/Artificial Artificial
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID 6B3Q,
Predicted Structure ID SPKB06255.cif
Physicochemical Information
Molecular weight 5986.17034
Aliphatic index 117.5925926
Isoelectric point 7.415519689
Charge (pH=7) 0.057847294
Topological polar surface area 2088.22
Aromaticity 0.12962963
Average rotatable bonds 3.388888889
Number of hydrogen bond donors 73
Number of hydrogen bond acceptors 73
X logP energy -7.93256
Hydropathy 
Literature Information
Title Improved secretion of recombinant human IL-25 in HEK293 cells using a signal peptide-pro-peptide domain derived from Trypsin-1
DOI 10.1007/s10529-020-03072-z,
Publication Year 2021
PubMed ID 33415569,
Patent ID NA,
