SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06244

Signal sequence   MGLGARGRRRRRRLMALPPPPPPMRALPLLLLLAGLGAAAP

Length  41

Organism  Mus musculus (Mouse)

UniProt ID  NA,

Motif  1..41



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06244.cif

Structure  SPKB06244.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4352.43174

Aliphatic index  112.195122

Isoelectric point  13.34510696

Charge (pH=7)   7.997957809

Topological polar surface area  1652.2

Aromaticity  0

Average rotatable bonds  3.268292683

Number of hydrogen bond donors  58

Number of hydrogen bond acceptors  53

X logP energy  -12.03734

Hydropathy 



Literature Information


Title  The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals

DOI  10.1371/journal.pone.0240498,

Publication Year  2020

PubMed ID  33296397,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.