SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06243

Signal sequence   MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAA

Length  39

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..39



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06243.cif

Structure  SPKB06243.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4104.00484

Aliphatic index  80.25641026

Isoelectric point  13.34510696

Charge (pH=7)   7.997957809

Topological polar surface area  1587.86

Aromaticity  0

Average rotatable bonds  3.025641026

Number of hydrogen bond donors  54

Number of hydrogen bond acceptors  51

X logP energy  -14.81734

Hydropathy 



Literature Information


Title  The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals

DOI  10.1371/journal.pone.0240498,

Publication Year  2020

PubMed ID  33296397,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.