SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06239

Signal sequence   MSPGKPGAGGAGTRRTGWRRRRRRRRLEAATRAP

Length  34

Organism  Placentals

UniProt ID  NA,

Motif  1..34



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06239.cif

Structure  SPKB06239.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3803.38154

Aliphatic index  26.17647059

Isoelectric point  13.15438935

Charge (pH=7)   10.99942796

Topological polar surface area  1838.18

Aromaticity  0.029411765

Average rotatable bonds  3.705882353

Number of hydrogen bond donors  72

Number of hydrogen bond acceptors  53

X logP energy  -25.64913

Hydropathy 



Literature Information


Title  The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals

DOI  10.1371/journal.pone.0240498,

Publication Year  2020

PubMed ID  33296397,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.