SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06238

Signal sequence   QMRPVSRVL

Length  9

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..9



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06238.cif

Structure  SPKB06238.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1085.33304

Aliphatic index  107.7777778

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  474.45

Aromaticity  0

Average rotatable bonds  3.888888889

Number of hydrogen bond donors  17

Number of hydrogen bond acceptors  15

X logP energy  -4.32156

Hydropathy 



Literature Information


Title  A signal peptide derived from Hsp60 induces protective cytotoxic T lymphocyte immunity against lymphoid malignancies independently of TAP and classical MHC-I

DOI  10.1016/j.canlet.2020.08.016,

Publication Year  2020

PubMed ID  32829008,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.