General Information
SPKB ID SPKB06237
Signal sequence MQRVNMIMAESPGAATACAAGYAASAEC
Length 28
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..28
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB06237.cif
Physicochemical Information
Molecular weight 2776.18284
Aliphatic index 56.42857143
Isoelectric point 4.25806771
Charge (pH=7) -1.123268612
Topological polar surface area 1143.83
Aromaticity 0.035714286
Average rotatable bonds 3.142857143
Number of hydrogen bond donors 41
Number of hydrogen bond acceptors 43
X logP energy -15.29553
Hydropathy 
Literature Information
Title Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assay
DOI 10.1182/bloodadvances.2020002520,
Publication Year 2020
PubMed ID 32766856,
Patent ID NA,
