SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06176

Signal sequence   MNKRGLYSKLGISVVGISLLMGVPTLIHA

Length  29

Organism  Streptococcus pneumoniae

UniProt ID  Q54727,

Motif  1..29



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  NA



Structure Information


PDB ID  2VW0,

Predicted Structure ID  SPKB06176.cif

Structure  SPKB06176.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3068.77284

Aliphatic index  141.0344828

Isoelectric point  10.90183646

Charge (pH=7)   3.087449597

Topological polar surface area  1156.19

Aromaticity  0.034482759

Average rotatable bonds  3.551724138

Number of hydrogen bond donors  41

Number of hydrogen bond acceptors  42

X logP energy  -8.46413

Hydropathy 



Literature Information


Title  Analysis of different signal peptides for the secretory production of Ama r 2 in gram-positive systems (Lactococcus lactis)

DOI  10.1016/j.micpath.2019.103819,

Publication Year  2020

PubMed ID  31669829,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.