SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06138

Signal sequence   MAKPLSKGGILVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKA

Length  47

Organism  Bacillus subtilis YncM

UniProt ID  O31803,

Motif  1..47



Activity Information


Pathway  Sec

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06138.cif

Structure  SPKB06138.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4488.43924

Aliphatic index  124.6808511

Isoelectric point  10.97760256

Charge (pH=7)   3.996955614

Topological polar surface area  1687.19

Aromaticity  0.021276596

Average rotatable bonds  3.14893617

Number of hydrogen bond donors  57

Number of hydrogen bond acceptors  61

X logP energy  -15.369

Hydropathy 



Literature Information


Title  Factors Influencing Recombinant Protein Secretion Efficiency in Gram-Positive Bacteria: Signal Peptide and Beyond

DOI  10.3389/fbioe.2019.00139,

Publication Year  2019

PubMed ID  31245367,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.