SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06134

Signal sequence   MRVLLFLLLSLFMLPAFS

Length  18

Organism  Escherichia coli

UniProt ID  NA,

Motif  1..18



Activity Information


Pathway  Sec

Natural/Artificial  Artificial

Subcellular location  Periplasmic space

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06134.cif

Structure  SPKB06134.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2111.71804

Aliphatic index  173.3333333

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  651.59

Aromaticity  0.166666667

Average rotatable bonds  3.722222222

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  24

X logP energy  1.62687

Hydropathy 



Literature Information


Title  In silico analysis of different signal peptides for the secretory production of recombinant human keratinocyte growth factor in Escherichia coli

DOI  10.1016/j.compbiolchem.2019.03.003,

Publication Year  2019

PubMed ID  30999249,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.