SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06128

Signal sequence   MMTKIKLLMLIIFYLIISASAHA

Length  23

Organism  Escherichia coli

UniProt ID  P77249,

Motif  1..23



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Periplasmic space

Secretion efficiency  NA

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06128.cif

Structure  SPKB06128.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2622.36744

Aliphatic index  165.6521739

Isoelectric point  10.24773591

Charge (pH=7)   2.087452908

Topological polar surface area  865.16

Aromaticity  0.086956522

Average rotatable bonds  3.869565217

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  34

X logP energy  -0.422

Hydropathy 



Literature Information


Title  In silico analysis of different signal peptides for the secretory production of recombinant human keratinocyte growth factor in Escherichia coli

DOI  10.1016/j.compbiolchem.2019.03.003,

Publication Year  2019

PubMed ID  30999249,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.