Peptide-Information

General Information

SPKB ID SPKB06116

Signal sequence MLSCRLQCALAALSIVLALGCVTG

Length 24

Organism Homo sapiens (Human)

UniProt ID NA,

Motif 1..24

Activity Information

Pathway SRP-dependent

Natural/Artificial Natural

Subcellular location ER

Secretion efficiency NA

Type Sec/SPI

Structure Information

PDB ID NA,

Predicted Structure ID SPKB06116.cif

Structure SPKB06116.cif

Very high (pLDDT > 90)

Confident (90 > pLDDT > 70)

Low (70 > pLDDT > 50)

Very low (pLDDT < 50)

Loading PAE…

Expected Position Error (Ångströms)

Physicochemical Information

Molecular weight 2407.00394

Aliphatic index 154.5833333

Isoelectric point 8.04679067

Charge (pH=7) 0.81205684

Topological polar surface area 898.3

Aromaticity 0

Average rotatable bonds 3.291666667

Number of hydrogen bond donors 35

Number of hydrogen bond acceptors 34

X logP energy -8.03753

Hydropathy

Literature Information

Title The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

Publication Year 2019

PubMed ID 30745438,

Patent ID NA,