Peptide-Information

General Information

SPKB ID SPKB06115

Signal sequence MLPGLALLLLAAWTARALEVPTDG

Length 24

Organism Homo sapiens (Human)

UniProt ID NA,

Motif 1..24

Activity Information

Pathway SRP-dependent

Natural/Artificial Natural

Subcellular location ER

Secretion efficiency NA

Type Sec/SPI

Structure Information

PDB ID 8KEW,

Predicted Structure ID SPKB06115.cif

Structure SPKB06115.cif

Very high (pLDDT > 90)

Confident (90 > pLDDT > 70)

Low (70 > pLDDT > 50)

Very low (pLDDT < 50)

Loading PAE…

Expected Position Error (Ångströms)

Physicochemical Information

Molecular weight 2493.00244

Aliphatic index 146.6666667

Isoelectric point 4.184407676

Charge (pH=7) -0.999797405

Topological polar surface area 907.79

Aromaticity 0.041666667

Average rotatable bonds 3.166666667

Number of hydrogen bond donors 31

Number of hydrogen bond acceptors 31

X logP energy -4.25643

Hydropathy

Literature Information

Title The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

Publication Year 2019

PubMed ID 30745438,

Patent ID NA,