SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06108

Signal sequence   MKKVLMAFIICLSLILSVLAAPPSGAK

Length  27

Organism  Bacillus subtilis

UniProt ID  NA,

Motif  1..27



Activity Information


Pathway  Sec

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06108.cif

Structure  SPKB06108.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2815.61364

Aliphatic index  151.8518519

Isoelectric point  10.51301932

Charge (pH=7)   2.935124482

Topological polar surface area  941.09

Aromaticity  0.037037037

Average rotatable bonds  3.444444444

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  37

X logP energy  -3.5501

Hydropathy 



Literature Information


Title  Systematic Screening of Optimal Signal Peptides for Secretory Production of Heterologous Proteins in Bacillus subtilis

DOI  10.1021/acs.jafc.8b04183,

Publication Year  2018

PubMed ID  30463403,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.