General Information
SPKB ID SPKB06106
Signal sequence MKVKGIRRNYQQLWRWGIMLLGICSA
Length 26
Organism Human immunodeficiency virus type 1 (HIV-1)
UniProt ID NA,
Motif 1..26
Activity Information
Pathway SRP-dependent
Natural/Artificial Artificial
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB06106.cif
Physicochemical Information
Molecular weight 3121.81924
Aliphatic index 105
Isoelectric point 11.5774086257443
Charge (pH=7) 4.93455916764432
Topological polar surface area 1229.87
Aromaticity 0.115384615384615
Average rotatable bonds 4.07692307692308
Number of hydrogen bond donors 46
Number of hydrogen bond acceptors 40
X logP energy -7.35619
Hydropathy 
Literature Information
Title Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations
DOI 10.1371/journal.ppat.1006812,
Publication Year 2018
PubMed ID 29370305,
Patent ID NA,
