SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06097

Signal sequence   MLVGQGAGLLGPAVVTAAVVLLLSGVGPAHG

Length  31

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..31



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  9C7U,

Predicted Structure ID  SPKB06097.cif

Structure  SPKB06097.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2825.40564

Aliphatic index  147.7419355

Isoelectric point  7.550323994

Charge (pH=7)   0.08889339

Topological polar surface area  1030.97

Aromaticity  0

Average rotatable bonds  2.806451613

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  37

X logP energy  -8.9559

Hydropathy 



Literature Information


Title  Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

DOI  10.1038/s41467-018-06188-z,

Publication Year  2018

PubMed ID  30217974,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.