General Information
SPKB ID SPKB06094
Signal sequence MGYFRCARAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCA
Length 42
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..42
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID 8B6L,
Predicted Structure ID SPKB06094.cif
Physicochemical Information
Molecular weight 4702.64674
Aliphatic index 81.66666667
Isoelectric point 11.85141591
Charge (pH=7) 5.874644674
Topological polar surface area 1786.06
Aromaticity 0.142857143
Average rotatable bonds 3.523809524
Number of hydrogen bond donors 69
Number of hydrogen bond acceptors 59
X logP energy -12.66608
Hydropathy 
Literature Information
Title Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
DOI 10.1038/s41467-018-06188-z,
Publication Year 2018
PubMed ID 30217974,
Patent ID NA,
