General Information
SPKB ID SPKB06089
Signal sequence MLEEAGEVLENMLKASCLPLGFIVFLPAVLLLVAPPLPAADA
Length 42
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..42
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID 6W6L,
Predicted Structure ID SPKB06089.cif
Physicochemical Information
Molecular weight 4377.32184
Aliphatic index 146.4285714
Isoelectric point 3.671908906
Charge (pH=7) -4.056738475
Topological polar surface area 1488.31
Aromaticity 0.047619048
Average rotatable bonds 3.238095238
Number of hydrogen bond donors 47
Number of hydrogen bond acceptors 54
X logP energy -4.8087
Hydropathy 
Literature Information
Title Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
DOI 10.1038/s41467-018-06188-z,
Publication Year 2018
PubMed ID 30217974,
Patent ID NA,
