SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06026

Signal sequence   MGAALRSLLACSFCVLLRA

Length  19

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06026.cif

Structure  SPKB06026.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1995.49014

Aliphatic index  138.9473684

Isoelectric point  8.834915637

Charge (pH=7)   1.874028245

Topological polar surface area  751.38

Aromaticity  0.052631579

Average rotatable bonds  3.421052632

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  27

X logP energy  -5.91126

Hydropathy 



Literature Information


Title  Vectors for Expression of Signal Peptide-Dependent Proteins in Baculovirus/Insect Cell Systems and Their Application to Expression and Purification of the High-Affinity Immunoglobulin Gamma Fc Receptor I in Complex with Its Gamma Chain

DOI  10.1007/s12033-017-0041-8,

Publication Year  2018

PubMed ID  29143175,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.