General Information
SPKB ID SPKB06013
Signal sequence MKWVTFISLLFLFSSAYS
Length 18
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..18
Activity Information
Pathway SRP-dependent
Natural/Artificial Artificial
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID 4BKE,
Predicted Structure ID SPKB06013.cif
Physicochemical Information
Molecular weight 2140.56784
Aliphatic index 108.3333333
Isoelectric point 9.298300651
Charge (pH=7) 0.996838851
Topological polar surface area 721.21
Aromaticity 0.277777778
Average rotatable bonds 3.666666667
Number of hydrogen bond donors 27
Number of hydrogen bond acceptors 27
X logP energy -1.8673
Hydropathy 
Literature Information
Title Improving Pertuzumab production by gene optimization and proper signal peptide selection
DOI 10.1016/j.pep.2017.04.013,
Publication Year 2017
PubMed ID 28476488,
Patent ID NA,
