General Information
SPKB ID SPKB06012
Signal sequence MDMRVPAQLLGLLLLWLPGARC
Length 22
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..22
Activity Information
Pathway SRP-dependent
Natural/Artificial Artificial
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID 7WUE,
Predicted Structure ID SPKB06012.cif
Physicochemical Information
Molecular weight 2467.08994
Aliphatic index 146.3636364
Isoelectric point 8.54983383
Charge (pH=7) 0.936449445
Topological polar surface area 876.82
Aromaticity 0.045454545
Average rotatable bonds 3.545454545
Number of hydrogen bond donors 31
Number of hydrogen bond acceptors 30
X logP energy -2.70046
Hydropathy 
Literature Information
Title Improving Pertuzumab production by gene optimization and proper signal peptide selection
DOI 10.1016/j.pep.2017.04.013,
Publication Year 2017
PubMed ID 28476488,
Patent ID NA,
