SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06011

Signal sequence   MLLPVPLLLGLLGLAAAL

Length  18

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06011.cif

Structure  SPKB06011.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1788.34864

Aliphatic index  227.7777778

Isoelectric point  6.099999998

Charge (pH=7)   -0.002015701

Topological polar surface area  540.44

Aromaticity  0

Average rotatable bonds  3.055555556

Number of hydrogen bond donors  17

Number of hydrogen bond acceptors  20

X logP energy  1.7988

Hydropathy 



Literature Information


Title  DNA vaccine encoding human papillomavirus antigens flanked by a signal peptide and a KDEL sequence induces a potent therapeutic antitumor effect

DOI  10.3892/ol.2017.5635,

Publication Year  2017

PubMed ID  28454292,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.