SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05997

Signal sequence   MSRMWLTTAAVFLTVTVAAVSA

Length  22

Organism  Trypanosoma brucei

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05997.cif

Structure  SPKB05997.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2326.79774

Aliphatic index  110.9090909

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  873.49

Aromaticity  0.090909091

Average rotatable bonds  3.227272727

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  32

X logP energy  -7.36123

Hydropathy 



Literature Information


Title  Species-specificity in endoplasmic reticulum signal peptide utilization revealed by proteins from Trypanosoma brucei and Leishmania

DOI  10.1042/bj3310521,

Publication Year  1998

PubMed ID  9531493,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.