SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05995

Signal sequence   MDCHTKETLGVTQWRRSTMLTLSLLYAITP

Length  30

Organism  Trypanosoma brucei

UniProt ID  NA,

Motif  1..30



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05995.cif

Structure  SPKB05995.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3467.07684

Aliphatic index  91

Isoelectric point  8.530402112

Charge (pH=7)   1.027988211

Topological polar surface area  1392.48

Aromaticity  0.066666667

Average rotatable bonds  3.733333333

Number of hydrogen bond donors  52

Number of hydrogen bond acceptors  50

X logP energy  -12.84836

Hydropathy 



Literature Information


Title  Species-specificity in endoplasmic reticulum signal peptide utilization revealed by proteins from Trypanosoma brucei and Leishmania

DOI  10.1042/bj3310521,

Publication Year  1998

PubMed ID  9531493,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.