SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05993

Signal sequence   MRISKPHLRSISIQCYLCLLLNSHFLTEAGIHVFILCFSAGLPKTEA

Length  47

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..47



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05993.cif

Structure  SPKB05993.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  5273.32164

Aliphatic index  120.4255319

Isoelectric point  8.521463661

Charge (pH=7)   2.086890565

Topological polar surface area  1968.84

Aromaticity  0.085106383

Average rotatable bonds  3.659574468

Number of hydrogen bond donors  72

Number of hydrogen bond acceptors  71

X logP energy  -14.21626

Hydropathy 



Literature Information


Title  Expression of two interleukin-15 mRNA isoforms in human tumors does not correlate with secretion: role of different signal peptides

DOI  10.1002/eji.1830270502,

Publication Year  1997

PubMed ID  9174591,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.