SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05992

Signal sequence   MMKRNLLAVIVPALLVAGGTANA

Length  23

Organism  Artificial

UniProt ID  NA,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05992.cif

Structure  SPKB05992.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2323.88404

Aliphatic index  144.3478261

Isoelectric point  11.65177567

Charge (pH=7)   1.997685954

Topological polar surface area  889.06

Aromaticity  0

Average rotatable bonds  3.304347826

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -6.83903

Hydropathy 



Literature Information


Title  The hydrophobic region of signal peptides is a determinant for SRP recognition and protein translocation across the ER membrane

DOI  10.1093/oxfordjournals.jbchem.a021583,

Publication Year  1997

PubMed ID  9089400,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.