General Information
SPKB ID SPKB05965
Signal sequence MKVGGIRRNYQHLWRWGIMLLGICSA
Length 26
Organism Human immunodeficiency virus type 1 (HIV-1)
UniProt ID NA,
Motif 1..26
Activity Information
Pathway SRP-dependent
Natural/Artificial Artificial
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB05965.cif
Physicochemical Information
Molecular weight 3059.70744
Aliphatic index 105
Isoelectric point 11.4320220137015
Charge (pH=7) 4.02576329240541
Topological polar surface area 1189.44
Aromaticity 0.115384615384615
Average rotatable bonds 3.88461538461538
Number of hydrogen bond donors 45
Number of hydrogen bond acceptors 39
X logP energy -7.15348999999996
Hydropathy 
Literature Information
Title Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations
DOI 10.1371/journal.ppat.1006812,
Publication Year 2018
PubMed ID 29370305,
Patent ID NA,
