SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05831

Signal sequence   MDLVVVLGLCLSCLLLLSLWKQSHGRSDGKSVKKRA

Length  36

Organism  Oryctolagus cuniculus (Rabbit)

UniProt ID  NA,

Motif  1..36



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05831.cif

Structure  SPKB05831.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3954.80954

Aliphatic index  132.5

Isoelectric point  10.34153488

Charge (pH=7)   3.964650169

Topological polar surface area  1573.01

Aromaticity  0.027777778

Average rotatable bonds  3.833333333

Number of hydrogen bond donors  59

Number of hydrogen bond acceptors  55

X logP energy  -13.15926

Hydropathy 



Literature Information


Title  Positive charges at the NH2 terminus convert the membrane-anchor signal peptide of cytochrome P-450 to a secretory signal peptide

DOI  10.1073/pnas.85.3.738,

Publication Year  1988

PubMed ID  3422456,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.