SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05824

Signal sequence   MKKSLVKASVAVATLVPMLSFA

Length  22

Organism  Escherichia coli

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  NA

Natural/Artificial  Natural

Subcellular location  Cytoplasmic membrane

Secretion efficiency  NA

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05824.cif

Structure  SPKB05824.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2291.87954

Aliphatic index  124.0909091

Isoelectric point  11.10307074

Charge (pH=7)   2.997099198

Topological polar surface area  824.61

Aromaticity  0.045454545

Average rotatable bonds  3.454545455

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  32

X logP energy  -5.5792

Hydropathy 



Literature Information


Title  Penetration of the signal sequence of Escherichia coli PhoE protein into phospholipid model membranes leads to lipid-specific changes in signal peptide structure and alterations of lipid organization

DOI  10.1021/bi00415a043,

Publication Year  1988

PubMed ID  3052582,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.