SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05796

Signal sequence   MLKFVVVICLVIMAITFA

Length  18

Organism  Illawarra wisharti (Illawarra funnel-web spider)

UniProt ID  Q5D231,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05796.cif

Structure  SPKB05796.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2011.65664

Aliphatic index  183.8888889

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  604.27

Aromaticity  0.111111111

Average rotatable bonds  3.611111111

Number of hydrogen bond donors  22

Number of hydrogen bond acceptors  24

X logP energy  1.9654

Hydropathy 



Literature Information


Title  Discovery of an MIT-like atracotoxin family: spider venom peptides that share sequence homology but not pharmacological properties with AVIT family proteins.

DOI  10.1016/j.peptides.2005.05.012,

Publication Year  2005

PubMed ID  15979762,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.