SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05646

Signal sequence   MNSLLMITACLILIGTVWA

Length  19

Organism  Centruroides limpidus (Mexican scorpion)

UniProt ID  Q8WRY4,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05646.cif

Structure  SPKB05646.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2063.60254

Aliphatic index  169.4736842

Isoelectric point  5.922539791

Charge (pH=7)   -0.063990417

Topological polar surface area  706.69

Aromaticity  0.052631579

Average rotatable bonds  3.473684211

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  27

X logP energy  -2.4361

Hydropathy 



Literature Information


Title  A novel class of peptide found in scorpion venom with neurodepressant effects in peripheral and central nervous system of the rat.

DOI  10.1016/s1570-9639(03)00155-9,

Publication Year  2003

PubMed ID  12818191,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.