SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05637

Signal sequence   MKKINIIKIVFIITVILISTISPIIKS

Length  27

Organism  Streptococcus pyogenes serotype M18 (strain MGAS8232)

UniProt ID  Q8NKX2,

Motif  1..27



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05637.cif

Structure  SPKB05637.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3039.92414

Aliphatic index  194.8148148

Isoelectric point  11.27833405

Charge (pH=7)   3.996804164

Topological polar surface area  1059.45

Aromaticity  0.037037037

Average rotatable bonds  3.925925926

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  39

X logP energy  -2.4998

Hydropathy 



Literature Information


Title  Nucleotide sequence of streptococcal pyrogenic exotoxin type C.

DOI  10.1128/iai.56.9.2518-2520.1988,

Publication Year  1988

PubMed ID  3045005,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.