SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05593

Signal sequence   MLGAKPHWLPGPLHSPGLPLVLVLLALGAGWA

Length  32

Organism  Homo sapiens (Human)

UniProt ID  Q6UW01,

Motif  1..32



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05593.cif

Structure  SPKB05593.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3283.02674

Aliphatic index  140.3125

Isoelectric point  9.703982825

Charge (pH=7)   1.179507447

Topological polar surface area  1056.66

Aromaticity  0.0625

Average rotatable bonds  2.9375

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  38

X logP energy  -1.8244

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.