SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05551

Signal sequence   MKIKTLAIVVLSALSLSSTAALA

Length  23

Organism  Escherichia coli

UniProt ID  Q47223,

Motif  1..23



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Fimbrium

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6Y7S,

Predicted Structure ID  SPKB05551.cif

Structure  SPKB05551.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2301.85404

Aliphatic index  165.6521739

Isoelectric point  10.80537956

Charge (pH=7)   1.997394232

Topological polar surface area  876.94

Aromaticity  0

Average rotatable bonds  3.391304348

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  33

X logP energy  -7.46

Hydropathy 



Literature Information


Title  A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.

DOI  10.1016/j.molcel.2010.02.015,

Publication Year  2010

PubMed ID  20347420,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.