SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05520

Signal sequence   MEKMAMKMLVIFVLGMNHWTCTG

Length  23

Organism  Bos taurus (Bovine)

UniProt ID  Q27967,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05520.cif

Structure  SPKB05520.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2672.35164

Aliphatic index  80.43478261

Isoelectric point  8.548069757

Charge (pH=7)   1.028103729

Topological polar surface area  920.88

Aromaticity  0.086956522

Average rotatable bonds  3.913043478

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  37

X logP energy  -3.8155

Hydropathy 



Literature Information


Title  Isolation and molecular cloning of a novel bone phosphoprotein related in sequence to the cystatin family of thiol protease inhibitors.

DOI  10.1074/jbc.270.1.431,

Publication Year  1995

PubMed ID  7814406,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.