SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05510

Signal sequence   MKLFVLLCVFVLCLASQEKQQDRE

Length  24

Organism  Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)

UniProt ID  Q24825,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05510.cif

Structure  SPKB05510.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2841.43784

Aliphatic index  121.6666667

Isoelectric point  6.310964863

Charge (pH=7)   -0.122561782

Topological polar surface area  1107.96

Aromaticity  0.083333333

Average rotatable bonds  4.125

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  38

X logP energy  -6.62043

Hydropathy 



Literature Information


Title  Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: isolation, primary structure, and pore formation in bacterial cytoplasmic membranes.

DOI  10.1111/j.1365-2958.1994.tb01325.x,

Publication Year  1994

PubMed ID  7715451,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.