SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05460

Signal sequence   MRSIGFYSVLALYVGAHVTED

Length  21

Organism  Bryonia dioica (Red bryony) (Bryonia cretica subsp. dioica)

UniProt ID  P98184,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05460.cif

Structure  SPKB05460.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2328.66804

Aliphatic index  106.6666667

Isoelectric point  5.454184442

Charge (pH=7)   -0.910589143

Topological polar surface area  911.65

Aromaticity  0.142857143

Average rotatable bonds  3.476190476

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  32

X logP energy  -6.67043

Hydropathy 



Literature Information


Title  Characterization of ribosome-inactivating proteins isolated from Bryonia dioica and their utility as carcinoma-reactive immunoconjugates.

DOI  10.1021/bc00029a008,

Publication Year  1994

PubMed ID  7849072,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.