SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05441

Signal sequence   MKLLFAIVALLALAFLCADISA

Length  22

Organism  Lumbricus terrestris (Common earthworm)

UniProt ID  P83472,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05441.cif

Structure  SPKB05441.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2307.92134

Aliphatic index  182.2727273

Isoelectric point  6.160569088

Charge (pH=7)   -0.063838966

Topological polar surface area  757.97

Aromaticity  0.090909091

Average rotatable bonds  3.409090909

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  28

X logP energy  -0.5124

Hydropathy 



Literature Information


Title  LTCI, a novel chymotrypsin inhibitor of the potato I family from the earthworm Lumbricus terrestris. Purification, cDNA cloning, and expression.

DOI  10.1016/j.cbpb.2005.12.023,

Publication Year  2006

PubMed ID  16469515,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.