SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05431

Signal sequence   MKFTATFLMMAIFVLMVEPGEC

Length  22

Organism  Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus)

UniProt ID  P81941,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05431.cif

Structure  SPKB05431.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2510.13914

Aliphatic index  88.63636364

Isoelectric point  4.258107901

Charge (pH=7)   -1.060735205

Topological polar surface area  806.71

Aromaticity  0.136363636

Average rotatable bonds  3.681818182

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  33

X logP energy  -1.5027

Hydropathy 



Literature Information


Title  Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder.

DOI  10.1074/jbc.272.18.12008,

Publication Year  1997

PubMed ID  9115266,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.