SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05429

Signal sequence   MHAIAPRLLLLFVLSGLPGTRG

Length  22

Organism  Human herpesvirus 2 (strain B4327UR) (HHV-2) (Human herpes simplex virus 2)

UniProt ID  P81780,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05429.cif

Structure  SPKB05429.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2332.87894

Aliphatic index  146.3636364

Isoelectric point  12.50011018

Charge (pH=7)   2.088886768

Topological polar surface area  849.78

Aromaticity  0.045454545

Average rotatable bonds  3.318181818

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  29

X logP energy  -4.63456

Hydropathy 



Literature Information


Title  Herpes simplex virus type 2 glycoprotein G-negative clinical isolates are generated by single frameshift mutations.

DOI  10.1128/JVI.73.12.9796-9802.1999,

Publication Year  1999

PubMed ID  10559290,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.