General Information
SPKB ID SPKB05425
Signal sequence MFSLKLFVVFLAVCICVSQA
Length 20
Organism Hirudinaria manillensis (Asian medical leech) (Poecilobdella manillensis)
UniProt ID P81492,
Motif 1..20
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB05425.cif
Physicochemical Information
Molecular weight 2218.80204
Aliphatic index 146
Isoelectric point 8.229691165
Charge (pH=7) 0.873739834
Topological polar surface area 725.79
Aromaticity 0.15
Average rotatable bonds 3.55
Number of hydrogen bond donors 27
Number of hydrogen bond acceptors 28
X logP energy -1.8224
Hydropathy 
Literature Information
Title Novel hirudin variants from the leech Hirudinaria manillensis. Amino acid sequence, cDNA cloning and genomic organization.
DOI 10.1111/j.1432-1033.1993.tb17924.x,
Publication Year 1993
PubMed ID 7685281,
Patent ID NA,
