SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05379

Signal sequence   MSKLFFVVFLCLIISVFA

Length  18

Organism  Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)

UniProt ID  P49125,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05379.cif

Structure  SPKB05379.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2077.65714

Aliphatic index  162.2222222

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  624.5

Aromaticity  0.222222222

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  24

X logP energy  1.6256

Hydropathy 



Literature Information


Title  Cloning and activity of a novel alpha-latrotoxin from red-back spider venom.

DOI  10.1016/j.bcp.2011.09.024,

Publication Year  2012

PubMed ID  22001442,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.