SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05338

Signal sequence   MKAWIFFLVCLAGRALA

Length  17

Organism  Oryctolagus cuniculus (Rabbit)

UniProt ID  P36233,

Motif  1..17



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05338.cif

Structure  SPKB05338.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1910.41194

Aliphatic index  132.3529412

Isoelectric point  9.833242293

Charge (pH=7)   1.935711238

Topological polar surface area  632.63

Aromaticity  0.176470588

Average rotatable bonds  3.529411765

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  22

X logP energy  -0.00893

Hydropathy 



Literature Information


Title  Osteonectin/SPARC is a product of articular chondrocytes/cartilage and is regulated by cytokines and growth factors.

DOI  10.1016/0167-4889(94)90209-7,

Publication Year  1994

PubMed ID  8130279,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.