SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB05157

Signal sequence   MGMRMMFTMILLVVLVTTVVS

Length  21

Organism  Conus planorbis (Planorbis cone)

UniProt ID  P0DUQ6,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB05157.cif

Structure  SPKB05157.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2373.08834

Aliphatic index  143.3333333

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  788.14

Aromaticity  0.047619048

Average rotatable bonds  3.761904762

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  32

X logP energy  -2.40373

Hydropathy 



Literature Information


Title  Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom.

DOI  10.1002/pmic.201500220,

Publication Year  2015

PubMed ID  26506909,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.