SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04963

Signal sequence   MSRLYAIILIALVFNVIMTIMPDMKVEA

Length  28

Organism  Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)

UniProt ID  C0HJQ5,

Motif  1..28



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04963.cif

Structure  SPKB04963.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3197.01714

Aliphatic index  153.2142857

Isoelectric point  6.487519403

Charge (pH=7)   -0.000942853

Topological polar surface area  1106.53

Aromaticity  0.071428571

Average rotatable bonds  3.785714286

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  41

X logP energy  -2.42573

Hydropathy 



Literature Information


Title  Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY.

DOI  10.1074/jbc.M115.637611,

Publication Year  2015

PubMed ID  25792741,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.