SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04909

Signal sequence   MKLQNTLILIGCLFLMGAMIGDA

Length  23

Organism  Tachypleus tridentatus (Japanese horseshoe crab)

UniProt ID  Q9U8X3,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04909.cif

Structure  SPKB04909.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2467.09924

Aliphatic index  144.3478261

Isoelectric point  6.160569088

Charge (pH=7)   -0.063838966

Topological polar surface area  873.25

Aromaticity  0.043478261

Average rotatable bonds  3.695652174

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  33

X logP energy  -4.0761

Hydropathy 



Literature Information


Title  Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins.

DOI  10.1074/jbc.274.37.26172,

Publication Year  1999

PubMed ID  10473569,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.