SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04890

Signal sequence   MKISFLLLALVICSIGWSEA

Length  20

Organism  Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)

UniProt ID  Q9NII6,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04890.cif

Structure  SPKB04890.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2194.71854

Aliphatic index  161

Isoelectric point  6.231833229

Charge (pH=7)   -0.062510328

Topological polar surface area  756.02

Aromaticity  0.1

Average rotatable bonds  3.6

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  28

X logP energy  -2.1203

Hydropathy 



Literature Information


Title  Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels.

DOI  10.1021/bi971044w,

Publication Year  1997

PubMed ID  9354615,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.