SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04844

Signal sequence   MKIFFAILLILAVCSMAIWTVNG

Length  23

Organism  Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)

UniProt ID  Q95NK7,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04844.cif

Structure  SPKB04844.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2555.23614

Aliphatic index  156.9565217

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  828.88

Aromaticity  0.130434783

Average rotatable bonds  3.565217391

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -0.5874

Hydropathy 



Literature Information


Title  Purification and pharmacological characterization of BmKK2 (alpha-KTx 14.2), a novel potassium channel-blocking peptide, from the venom of Asian scorpion Buthus martensi Karsch.

DOI  10.1016/j.toxicon.2003.11.028,

Publication Year  2004

PubMed ID  15208022,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.