SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04843

Signal sequence   MKFIIVLILISVLIATIVPVNEA

Length  23

Organism  Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)

UniProt ID  Q95NJ8,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04843.cif

Structure  SPKB04843.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2510.20044

Aliphatic index  211.7391304

Isoelectric point  6.408795646

Charge (pH=7)   -0.000535612

Topological polar surface area  841.6

Aromaticity  0.043478261

Average rotatable bonds  3.565217391

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  30

X logP energy  -0.1131

Hydropathy 



Literature Information


Title  BmKK4, a novel toxin from the venom of Asian scorpion Buthus martensi Karsch, inhibits potassium currents in rat hippocampal neurons in vitro.

DOI  10.1016/s0041-0101(03)00136-3,

Publication Year  2003

PubMed ID  12906891,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.