SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04816

Signal sequence   MEMKKIACGVLFAAASMTAVMA

Length  22

Organism  Arabidopsis thaliana (Mouse-ear cress)

UniProt ID  Q8S2W4,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04816.cif

Structure  SPKB04816.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2274.85674

Aliphatic index  89.09090909

Isoelectric point  8.540504393

Charge (pH=7)   0.937194639

Topological polar surface area  804.22

Aromaticity  0.045454545

Average rotatable bonds  3.5

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  33

X logP energy  -5.5851

Hydropathy 



Literature Information


Title  Post-translational modifications of arabinogalactan-peptides of Arabidopsis thaliana. Endoplasmic reticulum and glycosylphosphatidylinositol-anchor signal cleavage sites and hydroxylation of proline.

DOI  10.1074/jbc.M407594200,

Publication Year  2004

PubMed ID  15322080,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.