SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04774

Signal sequence   MGRLISVRFSLLVVFLSLSGIGAGLC

Length  26

Organism  Echis multisquamatus (Central Asian sand viper)

UniProt ID  Q7T2Q0,

Motif  1..26



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04774.cif

Structure  SPKB04774.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2709.34704

Aliphatic index  157.3076923

Isoelectric point  10.52640717

Charge (pH=7)   1.936002961

Topological polar surface area  995.54

Aromaticity  0.076923077

Average rotatable bonds  3.461538462

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  35

X logP energy  -6.93536

Hydropathy 



Literature Information


Title  Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the alpha2beta1 integrin.

DOI  10.1021/bi000428a,

Publication Year  2000

PubMed ID  10933804,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.